Drug intelligence / Profile preview

N-phenyl-1H-pyrrolo[2,3-b]pyridin-3-amine

Development stage
Unknown
Modality
Small Molecules
01

Overview

N‑phenyl‑1H‑pyrrolo[2,3-b]pyridin‑3‑amine is a synthetic small molecule belonging to the pyrrolopyridine class of organic compounds. It features a fused bicyclic structure with both pyrrole and pyridine rings and an aniline (N–phenyl) substitution at the 3-position. The compound has been studied as a kinase inhibitor—specifically targeting serine/threonine-protein kinase pim‐1—and is of interest in medicinal chemistry for its potential anti-cancer properties due to its ability to inhibit cell proliferation pathways. Its molecular formula is C13H11N3 and it has a molecular weight of approximately 209.25 g/mol. The compound appears as a solid under standard conditions and demonstrates moderate lipophilicity (logP ~ 2.7–3.4)[1][4][5].

Other names
1H-Pyrrolo[2,3-b]pyridin-3-amine, N-phenyl-2-phényl‑1H‑pyrrolo[2,3‑b]pyridin‑3‑amine918511–03–2 (CAS)
02

Targets

PIM1 (Proviral integration site for moloney murine leukemia virus kinase 1)

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